THE FORENSIC CHEMISTRY CENTER IN THE OFFICE OF REGULATORY AFFAIRS/OFFICE OF REGULATORY SCIENCE/MEDICAL PRODUCTS, TOBACCO AND SPECIALTY LABS (ORA/ORS/OMPTSLO) REQUIRES THE PURCHASE OF ONE (1) COMPACT HIGH PERFORMANCE ION MOBILITY - MASS SPECTROMETER SYSTEM (HPIMS-MS) IN SUPPORT OF FDA?S PROPOSED INCREASED PACKAGE INSPECTIONS FOR OPIOID PRODUCTS AND DRUGS AT INTERNATIONAL MAIL FACILITIES (IMFS) AND EXPRESS COURIER HUBS (ECHS). THIS IMS-MS INSTRUMENT WILL BE EVALUATED FOR FIELD DEPLOYMENT TO IMFS AND ECHS. THE INSTRUMENT WILL BE USED TO DEVELOP METHODS AND DRUG LIBRARIES FOR USE IN THE FIELD TO SCREEN INCOMING PACKAGES FOR OPIOID CONTAINING PRODUCTS, ILLICIT MEDICINES, FOREIGN UNAPPROVED DRUGS AND COUNTERFEIT PHARMACEUTICALS. THE USE OF FIELD PORTABLE INSTRUMENTATION PROVIDES THE ADVANTAGE OF POINT OF ENTRY SAMPLING AND THE ADDITION OF A COMPACT HPIMS-MS SYSTEM COULD PROVIDE RAPID IDENTIFICATION OF OPIOIDS AND DESIGNER OPIOID ANALOGS WITH MINIMAL OR NO SAMPLE PREPARATION. THE MINIMAL SAMPLE PREPARATION, ELIMINATION OF CHROMATOGRAPHY, AND RAPID ANALYSIS TIME WILL FACILITATE HIGH THROUGHPUT FIELD ANALYSES TO REDUCE THE NUMBER OF ILLEGAL OPIOID PRODUCTS AND DRUGS PASSING THROUGH OUR PORTS.