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TECHNOLOGY LICENSING OPPORTUNITY: Peptoid-Based Chelating Ligands for Selective Metal Chelation
Contact and place of performance
Caleb Ledgerwood
Los Alamos, NM 87545
USA
Peptoid-based chelating ligands offer a tunable platform for capturing and holding specific metal ions with high selectivity while resisting breakdown under physiological conditions. The technology combines structural flexibility with strong binding performance, which creates a practical path for applications where existing chelators fall short, including difficult metal removal in biological, environmental and separ...
View moreThe invention describes cyclic peptoid ligands that can be built from linear peptoids and then cyclized, with the binding profile tuned through functional groups such as catecholates, phosphonates, amines, guanidinium groups, phosphoramidates, N-hydroxypyridones and CMPO-like groups. Linker length, hydrophobicity, hydrophilicity and the number of coordinating groups can be adjusted to improve selectivity for specific ions and to support either tight retention for removal or controlled release after capture.
Advantages
Market Applications
TRL 4
US Patent Nos. 11,254,708; 11,859,018
LA-UR-26-23913
LANL Tech Partnerships: Unlock the Innovative Potential
Los Alamos National Laboratory offers a wide range of cutting-edge technologies and capabilities that may provide your company with a competitive edge in the market and unlock the innovative potential that can enhance, refine, and revolutionize your products.
LANL’s licensing program focuses on moving inventions developed by our researchers to commercial innovations. Patented and patent pending inventions and copyrighted software are available to existing and start-up companies through exclusive and non-exclusive licensing agreements. For specific discussions, please contact [email protected].
Note: This is not a call for external services for the development of this technology.
https://www.lanl.gov/engage/collaboration/feynman-center/partner-with-us/licensing-technology
m.lanl.gov/tech-search
The Department of Energy, through its contractor Triad at Los Alamos National Laboratory, is offering a technology licensing opportunity for peptoid-based chelating ligands. This technology utilizes cyclic peptoid scaffolds to capture and hold specific metal ions with high selectivity, specifically targeting hard metal ions such as actinides and lanthanides. Unlike traditional peptides, these peptoids feature side chains attached to nitrogen, providing increased resistance to hydrolysis and greater stability in physiological or harsh environmental conditions. The modular design allows for adjustments in ring size, side-chain chemistry, and linker length to tune the ligands for various applications, including environmental remediation, medical chelation therapy, imaging, and metal separations.
This special notice, identified by solicitation number S-133639, is categorized under NAICS 541714 for Research and Development in Biotechnology (except Nanobiotechnology) and PSC 6632 for Medical Laboratory Analysis Instruments. The technology, which has reached a Technical Readiness Level of 4, is protected under U.S. Patent Nos. 11,254,708 and 11,859,018. There is no set-aside designated for this opportunity, and the response deadline is June 30, 2026.
The licensing program aims to transition these innovations to commercial use through exclusive or non-exclusive licensing agreements for existing and start-up companies. The place of performance is Los Alamos, New Mexico, and the primary point of contact is Caleb Ledgerwood. Interested parties are invited to discuss the commercial potential of these patented inventions, which include the ability to adjust water or lipid compatibility for specific target environments.
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