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Chemistry Support for the DTT
Contact and place of performance
BANK, SARAH N
USA
PRE-SOLICITATION NOTICE Notice ID: 75N94026R00002 Title: Chemistry Support for the Division of Translational Toxicology (DTT) Description: This notice is related to a Request for Information (RFI)/Sources Sought Notice (SSN), 75N94026R00002, released on February 17, 2026. This acquisition is a full and open competition. This notice is issued on behalf of the National Institute of Environmental Health Sciences (NIEHS)...
View moreThis is a Research and Development contract requirement entitled, “Chemistry Support for the DTT”. This is NOT an NIH grant opportunity.
The National Institute of Environmental Health Sciences (NIEHS) seeks a contractor to address the present and anticipated future needs of NIEHS’s intramural Division of Translational Toxicology (DTT). The need is to continue to conduct research to discover how the environment influences the development and progression of human disease to promote healthier lives and to better understand how factors in the environment may impact human health. In addition, this requirement should produce information to predict adverse human health effects from chemical exposures.
DTT uses traditional and cutting-edge approaches to better understand how factors in the environment may impact human health. Such approaches include the conduct of toxicology studies on chemical, physical and biological agents, as well as non-chemical stressors, using in vitro and in vivo models of health and disease.
The contractor shall provide a broad range of chemistry R&D services in support of DTT and/or NTP research programs. Chemistry support is needed for a diverse range of test articles studied at DTT and/or NTP. The test articles can vary from a single chemical to a complex mixture with a wide variety of physical and chemical properties. The chemistry support required includes test article procurement and handling, comprehensive characterization of test articles, formulation of test article in a suitable vehicle to be administered in test models and determining concentration, analysis of biological matrices for concentration of test articles and metabolites, omics analyses of biological and environmental matrices, in vitro assays, absorption, distribution, metabolism, and excretion/toxicokinetic (ADME/TK) studies, In Vitro studies, and medium to high throughput chemistry support for in vitro toxicity screening are required for the successful execution of these studies.
All qualified organizations are encouraged to respond with a contract proposal.
Primary Point of Contact:
Sarah Bank
Contracting Officer
Email: [email protected]
The National Institutes of Health, specifically the National Institute of Environmental Health Sciences (NIEHS), requires chemistry research and development services to support the Division of Translational Toxicology (DTT). This requirement, identified under solicitation number 75N94026R00002, focuses on understanding how environmental factors influence human disease and predicting adverse health effects from chemical exposures. The contractor will provide a broad range of support for diverse test articles, ranging from single chemicals to complex mixtures. Work involves test article procurement and handling, comprehensive characterization, formulation in suitable vehicles for administration in test models, and the analysis of biological matrices for metabolites. Additionally, the scope includes omics analyses, in vitro assays, absorption, distribution, metabolism, and excretion/toxicokinetic (ADME/TK) studies, and medium to high throughput chemistry support for toxicity screening.
This acquisition is a full and open competition with no set-aside designated. The project is classified under NAICS 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AJ11 for General Science and Technology R&D Services; General Science and Technology; Basic Research. The government anticipates awarding a single cost-plus-fixed-fee contract featuring a 12-month base period and nine one-year option periods, with performance expected to begin on or about January 18, 2027.
The response deadline for this pre-solicitation notice is June 4, 2026, though the formal Request for Proposal (RFP) is expected to establish a proposal due date on or about July 20, 2026. Place of performance is within the United States. The Office of Acquisition and Logistics Management (OALM) is managing the procurement on behalf of NIEHS, with Sarah N. Bank serving as the primary point of contact. Details regarding the specific project requirements will be available in the forthcoming electronic solicitation.
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