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Chemistry Support for the DTT (NIEHS) - RFI/SSN
Contact and place of performance
BANK, SARAH N
USA
PRE-SOLICITATION NOTICE Notice ID: 75N94026R00002 Title: Chemistry Support for the Division of Translational Toxicology (DTT) Description: This notice is related to a Request for Information (RFI)/Sources Sought Notice (SSN), 75N94026R00002, released on February 17, 2026. This acquisition is a full and open competition. This notice is issued on behalf of the National Institute of Environmental Health Sciences (NIEHS)...
View moreThis is a Research and Development contract requirement entitled, “Chemistry Support for the DTT”. This is NOT an NIH grant opportunity.
The National Institute of Environmental Health Sciences (NIEHS) seeks a contractor to address the present and anticipated future needs of NIEHS’s intramural Division of Translational Toxicology (DTT). The need is to continue to conduct research to discover how the environment influences the development and progression of human disease to promote healthier lives and to better understand how factors in the environment may impact human health. In addition, this requirement should produce information to predict adverse human health effects from chemical exposures.
DTT uses traditional and cutting-edge approaches to better understand how factors in the environment may impact human health. Such approaches include the conduct of toxicology studies on chemical, physical and biological agents, as well as non-chemical stressors, using in vitro and in vivo models of health and disease.
The contractor shall provide a broad range of chemistry R&D services in support of DTT and/or NTP research programs. Chemistry support is needed for a diverse range of test articles studied at DTT and/or NTP. The test articles can vary from a single chemical to a complex mixture with a wide variety of physical and chemical properties. The chemistry support required includes test article procurement and handling, comprehensive characterization of test articles, formulation of test article in a suitable vehicle to be administered in test models and determining concentration, analysis of biological matrices for concentration of test articles and metabolites, omics analyses of biological and environmental matrices, in vitro assays, absorption, distribution, metabolism, and excretion/toxicokinetic (ADME/TK) studies, In Vitro studies, and medium to high throughput chemistry support for in vitro toxicity screening are required for the successful execution of these studies.
All qualified organizations are encouraged to respond with a contract proposal.
Primary Point of Contact:
Sarah Bank
Contracting Officer
Email: [email protected]
The National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS), requires chemistry research and development services to support the intramural Division of Translational Toxicology (DTT). This requirement, identified under solicitation number 75N94026R00002, focuses on investigating how environmental factors influence the development and progression of human disease. The contractor will provide a broad range of services including test article procurement and handling, comprehensive characterization of single chemicals and complex mixtures, formulation of test articles in suitable vehicles, and the analysis of biological matrices for metabolites. Additional activities include omics analyses, absorption, distribution, metabolism, and excretion/toxicokinetic (ADME/TK) studies, and high-throughput chemistry support for in vitro toxicity screening.
This acquisition is a full and open competition with no set-aside designated. The government classifies these services under NAICS 541715: Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AJ11: General Science and Technology R&D Services; General Science and Technology; Basic Research. Performance is located in the United States and is managed by the Office of Acquisition and Logistics Management (OALM). The anticipated award is a single cost-plus-fixed-fee contract consisting of a 12-month base period and nine one-year option periods, with work expected to begin on or about January 18, 2027.
The response deadline for this pre-solicitation notice is June 4, 2026, though the formal request for proposal (RFP) is expected to be released within 15 days of the notice publication. Proposals for the resulting solicitation are anticipated to be due on or about July 20, 2026. All inquiries are directed to Sarah N. Bank, the primary point of contact and Contracting Officer. There are currently zero attachments associated with this notice.
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