Opportunity

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) program to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. This research focuses on developing technologies capable of modifying the epigenome to create new opportunities for controlling DNA-protein interactions and studying the functions of rare or novel epigenetic modifications. The effort is intended to result in the demonstration of novel technologies for modifying nucleic acids in vitro.

This opportunity, identified by solicitation number DARPA-SN-26-67, is classified under NAICS code 541714 for Research and Development in Biotechnology (except Nanobiotechnology) and PSC code AC11 for National Defense R&D Services; Department of Defense - Military; Basic Research. Amendment 1 was issued to clarify submission instructions and deadlines. Administrative oversight is provided by Dr. Aric Lu within the DARPA Biological Technologies Office (BTO), categorized under Departmental Offices.

The response deadline for this notice is June 24, 2026. The solicitation includes two attachments: the original DARPA-SN-26-67 document posted on May 6, 2026, and Amendment 01 posted on May 18, 2026. This announcement follows the initial publication on May 6, 2026, with the most recent update occurring on May 18, 2026.