Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) program to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. This research opportunity seeks to develop technologies capable of modifying the epigenome to control DNA-protein interactions and study the functions of rare or novel epigenetic modifications. These efforts will result in the demonstration of new technologies for modifying nucleic acids in vitro.

This solicitation is categorized under NAICS 541714 for Research and Development in Biotechnology (except Nanobiotechnology) and PSC AC11 for National Defense R&D Services; Department of Defense - Military; Basic Research. Amendment 1 to the special notice was issued on May 18, 2026, to clarify submission instructions and deadlines. The notice includes two PDF attachments containing the original special notice and the subsequent amendment.

Prospective responders must submit materials by the deadline of June 24, 2026. The primary point of contact for this research opportunity is Dr. Aric Lu within the DARPA Biological Technologies Office (BTO). All inquiries and submissions are tracked under solicitation number DARPA-SN-26-67.