Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA-H), a component of the National Institutes of Health, is issuing this Innovative Solutions Opening (ISO) to support the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program. This initiative seeks to develop a critical illness Control Point Validation Engine designed to assess, predict, and treat immuno-inflammatory dysregulation before it leads to organ failure. The program's objectives include improving intensive care unit health outcomes while reducing stay durations and associated costs. ARPA-H intends to award multiple Other Transaction agreements under this solicitation, which is identified by solicitation number ARPA-H-SOL-26-139.

This procurement is classified under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for Health R&D Services; Health Care Services; Experimental Development. There is no assigned set-aside for this opportunity. The place of performance is the United States, and the primary point of contact is the ARPA-H RSO CIRCLE ISO Coordinator. The solicitation has undergone four amendments to provide revised documentation and to update the proposal submission timeline.

Interested parties must adhere to a multi-step submission schedule. Following a Proposer’s Day held on March 11, 2026, solution summaries were due by March 30, 2026. The final deadline for full proposals is May 28, 2026, at 1:00 PM ET. The solicitation includes 13 attachments, such as technical and management volume templates, price-cost proposal workbooks, and various amendment documents. All submissions and inquiries are managed through the agency's dedicated solutions portal.