Name | Type | Posted | Actions |
|---|---|---|---|
Att D - VOLUME2_PRICE-COST PROPOSAL WORKBOOK (Resource Sharing) CIRCLE_Amend 04.xlsx | XLSX | May 21, 2026 | |
ARPA-H-SOL-26-139_Amendment 04.docx | DOCX | May 21, 2026 | |
ARPA-H-SOL-26-139_Amendment 03.pdf | Apr 28, 2026 | ||
Att B - VOLUME 1_TECH-MANAGEMENT.pdf | Mar 23, 2026 | ||
ARPA-H-SOL-26-139_Amendment 02.pdf | Mar 23, 2026 | ||
ISO Amd 1 - CIRCLE.pdf | Feb 20, 2026 | ||
Att F - VOLUME 3_Administrative and National Policy - CIRCLE.docx | DOCX | Feb 17, 2026 | |
ISO - CIRCLE.pdf | Feb 17, 2026 | ||
Att E - VOLUME 3_Model OT Agreement - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att C - VOLUME 1_Task Description Document - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att A - Solution Summary Template - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att D - VOLUME 2_PRICE-COST PROPOSAL WORKBOOK - (Resource Sharing) - CIRCLE.xlsx | XLSX | Feb 17, 2026 | |
Att B - VOLUME 1_TECH - MANAGEMENT - CIRCLE.docx | DOCX | Feb 17, 2026 |
Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Contact and place of performance
ARPA-H RSO CIRCLE ISO Coordinator
USA
Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses. The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple...
View moreFull Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.
-------------------------- Amendment 1 --------------------------
The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.
-------------------------- Amendment 2 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 3 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 4 --------------------------
The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.
The Advanced Research Projects Agency for Health (ARPA-H) within the National Institutes of Health is seeking research and development for the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program. This solicitation, issued as an Innovative Solutions Opening under solicitation number ARPA-H-SOL-26-139, aims to establish a Control Point Validation Engine for critical illness. The program objective is to improve intensive care unit health outcomes and reduce patient stay times and associated costs by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.
This requirement is classified under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT. There is no set-aside for this opportunity, which is designated as NONE/NONE. ARPA-H anticipates that multiple Other Transaction Agreements will result from this announcement for performance within the United States.
The submission schedule requires solution summaries by March 30, 2026, with final proposals due by May 28, 2026. The solicitation includes 13 attachments, such as price-cost proposal workbooks, technical management volumes, and four amendments that provide revisions and schedule updates. The ARPA-H RSO CIRCLE ISO Coordinator is the primary point of contact for this solicitation.
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