Request for Information: Biomolecule Purification

The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) issued this special notice to gather information on novel methods for purifying large, complex molecules. The agency aims to identify technologies that support the creation of a universal purification platform capable of separating and recovering molecules with high specificity, purity, and yield from complex feedstocks. DARPA intends for this future platform to reduce processing time and complexity by eliminating the need for traditional multistep chromatography. This research falls under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AC12 for National Defense R&D Services; Department of Defense - Military; Applied Research.

The Request for Information (RFI) specifically seeks to understand current advances and challenges in purifying biologically produced proteins and other critical molecules. Additionally, the agency is interested in exploring new operational capabilities enabled by these novel purification approaches. Responses to solicitation number DARPA-SN-26-66 will inform the development of a potential new program. Submissions are due by June 8, 2026, and the primary point of contact is the DARPA-SN-26-66 Coordinator.

The notice was published on May 15, 2026, and last updated on May 21, 2026, by the Departmental Offices. Associated documentation includes two PDF attachments: the original DARPA-SN-26-66 notice and DARPA-SN-26-66-Amendment-01. No specific set-aside or place of performance was designated for this request.