Request for Information: Biomolecule Purification

The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) issued this special notice to gather information on novel methods for purifying large, complex molecules. The agency aims to identify technologies that could enable a universal purification platform capable of separating and recovering multiple complex molecules with high specificity, purity, and yield from complex feedstock. This initiative seeks to decrease purification time and complexity while eliminating the need for traditional multistep chromatography processes. DARPA intends to use the information gathered to understand current advances and challenges in purifying biologically produced proteins and other critical molecules, as well as the potential operational capabilities enabled by these novel approaches.

Responses to this Request for Information (RFI), identified by solicitation number DARPA-SN-26-66, are due by June 8, 2026. The requirement is categorized under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC code AC12 for National Defense R&D Services; Department of Defense - Military; Applied Research. The DARPA-SN-26-66 Coordinator serves as the point of contact for this notice, which includes two attachments: the original RFI document and one amendment. Information received through this notice will be used to inform the development of a future agency program.