Request for Information: Biomolecule Purification

The Defense Advanced Research Projects Agency (DARPA) Multi X Office (MXO) issued this special notice to gather information on novel methods for purifying large, complex molecules. The agency aims to identify technologies that support the creation of a universal purification platform capable of separating and recovering multiple complex molecules with high specificity, purity, and yield from complex feedstock. This initiative seeks to decrease purification time and complexity while eliminating the need for traditional multistep chromatography processes. DARPA intends to use the information received to understand current advances and challenges in purifying biologically produced proteins and other critical molecules, as well as the new operational capabilities these approaches might enable, to inform the development of a future program.

This request for information, identified by solicitation number DARPA-SN-26-66, is classified under NAICS 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AC12 for National Defense R&D Services; Department of Defense - Military; Applied Research. The notice was published on May 15, 2026, and updated on May 21, 2026, with a response deadline of June 8, 2026. Documentation associated with this notice includes two PDF attachments: the original DARPA-SN-26-66 file and Amendment 01. The primary point of contact for this requirement is the DARPA-SN-26-66 Coordinator.